Infected cell protein 0 532 ICP0 ICP0_EHV1V RING-finger E3 ubiquitin ligase that degrades host SP100, one of the major components of ND10 nuclear bodies, thereby disrupting the organization of these bodies. Acts as a transcriptional activator of viral promoters and enhances infectivity. Additionally, inhibits host IRF3 activation to prevent interferon production by the infected cells (By similarity). :PTM: Auto-ubiquitinated (By similarity). MATVAERCPICLEDPSNYSMALPCLHAFCYVCITRWIRQNPTCPLCKVPVESVVHTIESDSEFKETKVSVDFDYDSEEDEDSFEGQFLAVDSGDAPANISAWNGPMAFVPLNANGTAGAPRLQPLVDWLVERLDQLFETPELALVMRNIVMDTLCEHGCNEEELTRQFWPMFHEDTVPFVTDLIVQAELCVASRPILPIARGRGVEYIDSSSSSSSSEEETDSDIEVDPNNLTDPEDTSDETSTDNSSAQAPRQEDSRPARARPGPPTRGRRRGRRPAAPGPASRRSARLRRRQPRTNSRTNGGDNGEIIDLTLDSDGDTEPADVSGSLNTTDQPVLIPDEEEAAPASPHTSSNSAIICLVSELTPESEEPPRDQPVAPSGSSAGERPMRPRCSLREFARRFMALAPRDSSTSEAAGPSRLGAGPRATEPFSVAVVLVDRSSEGAGLFGGRFAQHVRRRTEDESARRRGNVLLRPRRQSVPPVPYPDIASTSPLIRQGGQRVRDLQRAFQTQPAEPEEMRCPHNCQRYRRNQ E3 ubiquitin-protein ligase ICP0